ANESTHESIOLOGIE REANIMATION HAITI (HUEH)

Frederick Allen , MD * ,  James Riopelle , MD †  and  Ashish Sinha , MD, PhD * + Author Affiliations From the  * Department of Anesthesiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; and  † Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Address correspondence and reprint requests to Frederick Allen, MD,  Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104 . Address e-mail to  fredallenmd@gmail.com .   Next Section Abstract We describe a case of inadvertent intracranial placement of a nasotracheal tube in a patient with an undiagnosed major congenital cranial anomaly (a variant of Goldenhar syndrome, which included absence of the cribriform plate). We believe that this is the first reported case in which this complication arose as a result of a congenital abnormality rather than traumatic or iatrogenic disruption of the skull base. We concl

M. M. R. F. Struys 1 , 2 , * ,  M. Sahinovic 1 ,  B. J. Lichtenbelt 1 ,  H. E. M. Vereecke 1  and A. R. Absalom 1 + Author Affiliations 1 Department of Anesthesiology , University Medical Center Groningen, University of Groningen,  Hanzeplein 1, 9700 RB Groningen , The Netherlands 2 Department of Anaesthesia , Ghent University,  De Pintelaan 185, 9000 Ghent , Belgium * ↵ Corresponding author: Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. E-mail: m.m.r.f.struys@anest.umcg.nl   Next Section Abstract This review discusses the ways in which anaesthetists can optimize anaesthetic–analgesic drug administration by utilizing pharmacokinetic and pharmacodynamic information. We therefore focus on the dose–response relationship and the interactions between i.v. hypnotics and opioids. For i.v. hypnotics and opioids, models that accurately predict the time course of drug d