Accéder au contenu principal

A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity

Par
Non-steroidal anti-inflammatory drugs (NSAIDs) represent a diverse class of drugs and are among the most commonly used analgesics for arthritic pain worldwide, though long-term use is associated with a spectrum of adverse effects. The introduction of cyclooxygenase-2-selective NSAIDs early in the last decade offered an alternative to traditional NSAIDs with similar efficacy and improved gastrointestinal tolerability; however, emerging concerns about cardiovascular safety resulted in the withdrawal of two agents (rofecoxib and valdecoxib) in the mid-2000s and, subsequently, in an overall reduction in NSAID use. It is now understood that all NSAIDs are associated with some varying degree of gastrointestinal and cardiovascular risk. Guidelines still recommend their use, but little is known of how patients use these agents. While strategies and guidelines aimed at reducing NSAID-associated complications exist, there is a need for evidence-based algorithms combining cardiovascular and gastrointestinal factors that can be used to aid treatment decisions at an individual patient level.

 http://www.docguide.com/turbulent-decade-nsaids-update-current-concepts-classification-epidemiology-comparative-efficacy-and?tsid=6#comments

Commentaires

Enregistrer un commentaire

Posts les plus consultés de ce blog

The Muse Brooklyn

Par
http://abcirque.com http://www.amny.com/things-to-do/circus-class-at-the-muse-brooklyn-teaches-acrobatic-skills-1.13781898 https://www.instagram.com/p/Bx-D67pAxGz/ https://www.instagram.com/p/Bx7e3GFgpp2/ https://www.instagram.com/p/Bx5xpoPn_hm/ https://www.instagram.com/p/Bx40FSvj2Tf/ https://www.instagram.com/p/Bx0p224DkxE/ https://www.instagram.com/p/BxzxjhqFO1S/ https://www.instagram.com/p/BxyJmIaAeSd/ https://www.instagram.com/p/BxxweSaF6q4/ https://www.instagram.com/p/BxxSsdcAjFg/ https://www.instagram.com/p/Bxvr0SSgpPs/ https://new.mta.info/L-Project http://themusegowanus.com http://instagram.com/themusebrooklyn https://www.facebook.com/TheMuseBrooklyn/ https://twitter.com/TheMuseBrooklyn https://www.youtube.com/channel/UCkzh62AIfOI7XU3I0P6rWIQ
Enregistrer un commentaire
Lire la suite

Fw:

Par
Consider this message as your last warning. We hacked your system! We have copied all the data from your device to our own servers. Curious videos were recorded from your camera and your actions while watching porn. Your device was infected with our virus when you visited the porn site. The Trojan virus gives us full access, allows us to control your device. The virus allows not only to see your screen, but also to turn on your camera, microphone, without your knowledge. We took over the video from your screen and camera, then we mounted a video in which you can see you watching porn in one part of the screen and masturbating in the other. But that’s not all! We have access to all the contacts in your phone book and social networks. It won’t take us long to send this video to your friends, family and friends on social networks, messengers and email in minutes. We have a lot of audio recordings of your personal conversations, where a lot of “intere...
Enregistrer un commentaire
Lire la suite

Systemic Lidocaine Decreased the Perioperative Opioid Analgesic Requirements but Failed to Reduce Discharge Time After Ambulatory Surgery

Par
Perioperative systemic lidocaine significantly reduces opioid requirements in the ambulatory setting without affecting time to discharge. Postoperative pain is the most common reason for delay in discharge and unplanned hospital admission after ambulatory surgery. 1–3 Because postoperative pain is to a large extent an inflammatory phenomenon, administration of systemic local anesthetics, which have inflammatory modulatory properties, 4 could significantly reduce pain and therefore allow more rapid discharge. 5 Lidocaine has an excellent safety record when administered by low-dose infusion. 5–7 However, whereas decreased hospital stay after inpatient surgery has been demonstrated, the effect of intraoperative and early postoperative lidocaine infusion on duration of stay after ambulatory surgery is not known. Although it see...
Enregistrer un commentaire
Lire la suite