Accéder au contenu principal

Human Subthalamic Neuron Spiking Exhibits Subtle Responses to Sedatives

Par

Human Subthalamic Neuron Spiking Exhibits Subtle Responses to Sedatives

MacIver, M. Bruce M.Sc., Ph.D.*; Bronte-Stewart, Helen M. M.D., M.S.E.†; Henderson, Jaimie M. M.D.‡; Jaffe, Richard A. M.D., Ph.D.*; Brock-Utne, John G. M.D., Ph.D.*

Free Access
Article Outline
Collapse Box

Author Information

Collapse Box

Abstract

Background: During deep brain stimulation implant surgery, microelectrode recordings are used to map the location of targeted neurons. The effects produced by propofol or remifentanil on discharge activity of subthalamic neurons were studied intraoperatively to determine whether they alter neuronal activity.
Methods: Microelectrode recordings from 11 neurons, each from individual patients, were discriminated and analyzed before and after administration of either propofol or remifentanil. Subthalamic neurons in rat brain slices were recorded in patch-clamp to investigate cellular level effects.
Results: Neurons discharged at 42 ± 9 spikes/s (mean ± SD) and showed a common pattern of inhibition that lasted 4.3 ms. Unique discharge profiles were evident for each neuron, seen using joint-interval analysis. Propofol (intravenous bolus 0.3 mg/kg) produced sedation, with minor effects on discharge activity (less than 2.0% change in frequency). A prolongation of recurrent inhibition was evident from joint-interval analysis, and propofol's effect peaked within 2 min, with recovery evident at 10 min. Subthalamic neurons recorded in rat brain slices exhibited inhibitory synaptic currents that were prolonged by propofol (155%) but appeared to lack tonic inhibitory currents. Propofol did not alter membrane potential, membrane resistance, current-evoked discharge, or holding current during voltage clamp. Remifentanil (0.05 mg/kg) had little effect on overall subthalamic neuron discharge activity and did not prolong recurrent inhibition.
Conclusions: These results help to characterize the circuit properties and feedback inhibition of subthalamic neurons and demonstrate that both propofol and remifentanil produce only minor alterations of subthalamic neuron discharge activity that should not interfere with deep brain stimulation implant surgery.
LIENS

Commentaires

Enregistrer un commentaire

Posts les plus consultés de ce blog

The Muse Brooklyn

Par
http://abcirque.com http://www.amny.com/things-to-do/circus-class-at-the-muse-brooklyn-teaches-acrobatic-skills-1.13781898 https://www.instagram.com/p/Bx-D67pAxGz/ https://www.instagram.com/p/Bx7e3GFgpp2/ https://www.instagram.com/p/Bx5xpoPn_hm/ https://www.instagram.com/p/Bx40FSvj2Tf/ https://www.instagram.com/p/Bx0p224DkxE/ https://www.instagram.com/p/BxzxjhqFO1S/ https://www.instagram.com/p/BxyJmIaAeSd/ https://www.instagram.com/p/BxxweSaF6q4/ https://www.instagram.com/p/BxxSsdcAjFg/ https://www.instagram.com/p/Bxvr0SSgpPs/ https://new.mta.info/L-Project http://themusegowanus.com http://instagram.com/themusebrooklyn https://www.facebook.com/TheMuseBrooklyn/ https://twitter.com/TheMuseBrooklyn https://www.youtube.com/channel/UCkzh62AIfOI7XU3I0P6rWIQ
Enregistrer un commentaire
Lire la suite

HTML5 Games On Android

Par
On my last hollidays, I made two HTML5 games, and published on android market. Nowadays javascript has powerful libraries for doing almost everything, and also there are several compilers from java or c code to javascript, converting opengl c code to html5 canvas, but definitely, javascript execution is slower than dalvik applications, and of course much slower than arm c libs. For improving the speed of sounds and images loader, I have used javascript asynchronous execution and scheduling priority has been controlled with setTimeout/setInterval which deprioritize or priorize a code block. This games are published on the android market here: Android Planets and here: Far Planet Related news Hacker Hardware Tools Pentest Tools Port Scanner Hacker Tools For Mac Tools Used For Hacking Hacker Techniques Tools And Incident Handling Easy Hack Tools Hacking Tools Kit Hacking Tools Usb Hacker Hardware Tools Hacker Tools Hardware Hack Tools For Windows Hacking Tools For G...
Enregistrer un commentaire
Lire la suite

"Abre Las Puertas A La Inclusión": La Campaña De Donativos De ASCM Para Hacer Su Sede Más Accesible

Par
La Asociación Sociocultural ASCM lanza la campaña de recaudación de fondos: "Abre las puertas a la inclusión", con el objetivo de dotar su sede de una puerta automática.                                                       Campaña "Abre las puertas a la inclusión": Vídeo promocional.  La Asociación Sociocultural ASCM lanza, hoy, una campaña de recaudación de fondos para mejorar la accesibilidad de su sede de Ferrol y adaptarse a las medidas de seguridad y prevención que exige la nueva normalidad. "Abre las puertas a la inclusión" es el slogan de esta campaña de donativos, que se extenderá hasta el 24 de julio, y que busca la colaboración de la ciudadanía para lograr reunir los 3.599 euros necesarios para dotar su local de una puerta automática. ASCM lleva, desde su fundación en 1987, reivindicando la necesidad de pensar en clave de accesibilidad un...
Enregistrer un commentaire
Lire la suite